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In the SURMOUNT-1 trial, adults taking Zepbound 15 mg lost an average of 20.9% of their body weight over 72 weeks, compared to 3.1% with placebo

10.1038/ncomms15500 Nat

The multi-mode synergistic effect of ZFPG NPs, especially along with their GSH depletion ability, can induce GPx4 inactivation-mediated excessive accumulation of LPO, ultimately leading to efficient ferroptosis

Given the drugs newness and skyrocketing popularity, it is important to systematically examine their effects on all body systems leaving no stone unturned to understand what they do and what they dont do, said the studys senior author, Ziyad Al-Aly, MD, a clinical epidemiologist and nephrologist who treats patients at the WashU Medicine-affiliated John J

3 , e0152014 (2015)